Tetrabenazine Mechanism Of Action
14280380 PubMed - indexed for MEDLINE MeSH Terms. Rats injected with L-5-hydroxytryptophan L-5-HTP 30 mgkg the immediate precursor of 5-hydroxytryptamine 5-HT showed the characteristic bison appearance pitosis and catalepsy. Tetrabenazine Wikipedia Tetrabenazine Chorea is one of the most common and debilitating motor symptoms experienced by people with Huntingtons Disease. Tetrabenazine mechanism of action . Tetrabenazine depletes presynaptic dopamine norepinephrine and serotonin storage and antagonizes postsynaptic dopamine receptors. A study was undertaken to gain an understanding of the biochemical mechanism whereby tetrabenazine TBZ produces a sedative effect on the locomotor activity of rats. Because until recently the drug had not been. The transporters exchange protons for monoamines using a proton electrochemi-cal gradient generated by a vacuole ATP. Mechanism of Action Reversibly inhibits human vesicular monoamine transporter type 2 VMAT2 resulting in decreased up